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KMID : 0370220030470060345
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Yakhak Hoeji
2003 Volume.47 No. 6 p.345 ~ p.351
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Cell Viability and Flow Cytometry Analysis of a Novel Antitumor Agent, Heptaplatin in Human Melanoma Cell Line, SK-MEL-28
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최수라/Choi SL
명평근/Myung PK
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Abstract
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Heptaplatin, cis-Malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3- dioxolane]platinum(II), is a novel platinum-based antitumor agent with clinical potential against human stomach cancer and the 3rd generation of the cisplatin. This study was performed to study how cisplain, heptaplatin and sunpla which is a mixture of heptaplatin and mannitol (w:w=1:2) affect cell viability of SK-MEL-28 human melanoma cell line. Heptaplatin (IC50; 95.35 μM) and sunpla (IC50; 10.95 μM) were less effect than cisplatin (IC50; 10.92 μM) on the SK-MEL-28 cells. By cell cycle analysis using flow cytometry, it was identified that the cells were arrested at G2/M phase by cisplatin, heptaplatin and sunpla, and percentage of cell death group was increased according to increasing of time and concentration. These results suggest that cisplatin, heptaplatin and sunpla are a novel anticancer agent against human melanoma cell.
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